Monosomal karyotype in primary myelofibrosis is detrimental to both overall and leukemia-free survival.

@article{Vaidya2011MonosomalKI,
  title={Monosomal karyotype in primary myelofibrosis is detrimental to both overall and leukemia-free survival.},
  author={Rakhee Vaidya and Domenica Caramazza and Kebede H Begna and Naseema Gangat and Daniel L Van Dyke and Curtis A. Hanson and Animesh Pardanani and Ayalew Tefferi},
  journal={Blood},
  year={2011},
  volume={117 21},
  pages={5612-5}
}
Survival in cytogenetically high-risk patients with acute myeloid leukemia or myelodysplastic syndromes is significantly worse in the presence of a monosomal karyotype (MK). The objective of the present study was to determine whether the same held true for primary myelofibrosis. Among 793 primary myelofibrosis patients seen at our institution, 62 displayed an unfavorable karyotype by way of complex karyotype (n = 41) or sole trisomy 8 (n = 21). Seventeen (41%) of the 41 patients with complex… CONTINUE READING

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