Monosomal karyotype in MDS: explaining the poor prognosis?

  title={Monosomal karyotype in MDS: explaining the poor prognosis?},
  author={Julie Schanz and Heinz Tuechler and Francesc Sol{\'e} and Mar Mallo and Elisa Lu{\~n}o and Jos{\'e} D{\'i}az Cervera and Javier Grau and Barbara Hildebrandt and Marilyn L. Slovak and Kazuma Ohyashiki and Christian Steidl and Christa Fonatsch and Michael Pfeilstoecker and Thomas Noesslinger and Peter Valent and Aristoteles Giagounidis and Carlo Aul and Michael Luebbert and Reinhard Stauder and O. v. Krieger and M M Le Beau and J. Michael Bennett and Peter Greenberg and Ulrich Germing and Detlef Haase},
Monosomal karyotype (MK) is associated with an adverse prognosis in patients in acute myeloid leukemia (AML). This study analyzes the prognostic impact of MK in a cohort of primary, untreated patients with myelodysplastic syndromes (MDS). A total of 431 patients were extracted from an international database. To analyze whether MK is an independent prognostic marker in MDS, cytogenetic and clinical data were explored in uni- and multivariate models regarding overall survival (OS) as well as AML… CONTINUE READING
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