Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?

@inproceedings{Orlowsky2014MonosodiumUC,
  title={Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?},
  author={Eric W. Orlowsky and Thomas V. Stabler and Eul{\'a}lia Montell and Josep Mar{\'i}a Verg{\`e}s and Virginia B. Kraus},
  booktitle={BMC musculoskeletal disorders},
  year={2014}
}
BACKGROUND Chondroitin Sulphate (CS), a natural glycosaminoglycan of the extracellular matrix, has clinical benefit in symptomatic osteoarthritis but has never been tested in gout. In vitro, CS has anti-inflammatory and positive effects on osteoarthritic chondrocytes, synoviocytes and subchondral bone osteoblasts, but its effect on macrophages is unknown. The purpose of our study was to evaluate the in vitro effects of CS on monosodium urate (MSU)-stimulated cytokine production by macrophages… CONTINUE READING
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