Monosialoanglioside (GM1) prevents lead-induced neurotoxicity on long-term potentiation, SOD activity, MDA levels, and intracellular calcium levels of hippocampus in rats

@article{She2008MonosialoangliosideP,
  title={Monosialoanglioside (GM1) prevents lead-induced neurotoxicity on long-term potentiation, SOD activity, MDA levels, and intracellular calcium levels of hippocampus in rats},
  author={Jia-Qi She and Ming Wang and Da-Miao Zhu and Mingliang Tang and Ju-tao Chen and Lang Wang and Di-yun Ruan},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={379},
  pages={517-524}
}
Lead (Pb2+) is one of the most common neurotoxic metals present in our environment. Chronic or acute exposure to Pb2+ causes impairment to the central nervous system (CNS). As one potent useful tool in the attempt to protect against impairment and promote functional recovery of the CNS, gangliosides are hopeful for recovering Pb2+ neurotoxicity. The aim of this study is to investigate the effects of monosialoganglioside (GM1) on the Pb2+-induced impairments of synaptic plasticity, antioxidant… CONTINUE READING
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