Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene.

@article{Selva2007MonosaccharideinducedLR,
  title={Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene.},
  author={D. Selva and K. Hogeveen and S. Innis and G. Hammond},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 12},
  pages={
          3979-87
        }
}
The liver produces plasma sex hormone-binding globulin (SHBG), which transports sex steroids and regulates their access to tissues. In overweight children and adults, low plasma SHBG levels are a biomarker of the metabolic syndrome and its associated pathologies. Here, we showed in transgenic mice and HepG2 hepatoblastoma cells that monosaccharides (glucose and fructose) reduce human SHBG production by hepatocytes. This occurred via a downregulation of hepatocyte nuclear factor-4alpha (HNF… Expand
Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome
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  • G. Hammond
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Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4alpha.
Sex hormone-binding globulin gene expression and insulin resistance.
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