Monophosphoryl lipid A-induced delayed preconditioning is mediated by calcitonin gene-related peptide.

@article{He2001MonophosphorylLA,
  title={Monophosphoryl lipid A-induced delayed preconditioning is mediated by calcitonin gene-related peptide.},
  author={Shajin He and Han-wu Deng and Y J Li},
  journal={European journal of pharmacology},
  year={2001},
  volume={420 2-3},
  pages={
          143-9
        }
}
  • S. HeH. DengY. Li
  • Published 25 May 2001
  • Biology, Chemistry
  • European journal of pharmacology

Delayed cardioprotection induced by nitroglycerin is mediated by alpha-calcitonin gene-related peptide

The present results suggest that the delayed cardioprotection induced by nitroglycerin is mediated mainly by the α-CGRP isoform via the NO-cGMP pathway.

Monophosphoryl Lipid A-Induced Delayed Preconditioning in Rat Small Intestine Is Mediated by Calcitonin Gene-Related Peptide

Monophosphoryl lipid A pharmacologically mimics delayed preconditioning and the protective effects are related to the stimulation of calcitonin gene-related peptide release in rat small intestine.

Pharmacological preconditioning with monophosphoryl lipid A improves post ischemic diastolic function and modifies TNF-alpha synthesis.

  • R. SharonyI. Frolkis G. Uretzky
  • Biology, Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2005

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It is suggested that MLA pretreatment may enhance iNOS enzyme activity by MLA during ischemia which may be responsible for the observed cardioprotection.

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Pretreatment with capsaicin induces the early and delayed cardioprotection, which may be related to stimulation of CGRP release in the rat.