Mononucleotide metabolism in the rat brain after transient ischemia.

  title={Mononucleotide metabolism in the rat brain after transient ischemia.},
  author={Hiroshi Onodera and Katsuya Iijima and Kyuya Kogure},
  journal={Journal of neurochemistry},
  volume={46 6},
Nucleotide metabolism was studied in rats during and following the induction of 10 min of forebrain ischemia (four-vessel occlusion model). Purine and pyrimidine nucleotides, nucleotides, and bases in forebrain extracts were quantitated by HPLC with an ultraviolet detector. Ischemia resulted in a severe reduction in the concentration of nucleoside triphosphates (ATP, GTP, UTP, and CTP) and an increase in the concentration of AMP, IMP, adenosine, inosine, hypoxanthine, and guanosine. During the… CONTINUE READING


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