Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma.

  title={Mononuclear phagocytes migrate into the murine cochlea after acoustic trauma.},
  author={Keiko Hirose and Christopher M Discolo and Jodi R Keasler and Richard M Ransohoff},
  journal={The Journal of comparative neurology},
  volume={489 2},
Acoustic injury results in destruction of hair cells and numerous nonsensory cells of the cochlea. How these injured structures undergo repair is not well understood. This study was designed to examine the cochlea for the presence of mononuclear phagocytes after tissue injury caused by noise damage. We used octave band noise (8--16 kHz) at three levels (106, 112, and 120 dB) for 2 hours and studied the mice at 1, 3, 7, and 14 days after noise exposure to determine how noise affected hearing… CONTINUE READING
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