Mononuclear cell-mediated modulation of synovial cell metabolism. II. Increased hyaluronic acid synthesis by a monocyte cell factor (MCF).

@article{Bocquet1985MononuclearCM,
  title={Mononuclear cell-mediated modulation of synovial cell metabolism. II. Increased hyaluronic acid synthesis by a monocyte cell factor (MCF).},
  author={Jean Claude Bocquet and Monique Langris and Michelle Daireaux and V. Jouis and Jean Pierre Pujol and Roland B{\'e}liard and G. Loyau},
  journal={Experimental cell research},
  year={1985},
  volume={160 1},
  pages={
          9-18
        }
}
Treatment of cultured human synovial cells with a mononuclear cell factor (MCF) enhanced their ability to synthesize glycosaminoglycans (GAG), but GAG repartition between extracellular, pericellular and intracellular compartments was found to be the same as in control. Hyaluronic acid (HA) production, which represents 80-90% of all secreted GAG, was stimulated 2 1/2-3-fold, but the HA molecular weight was not modified. The MCF increased the hyaluronate synthetase activity of synovial cells in… CONTINUE READING
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