Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.

@article{Itoh1993MononuclearCI,
  title={Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.},
  author={Naoyuki Itoh and Toshiaki Hanafusa and Akira Miyazaki and Jun Miyagawa and Kazuya Yamagata and Koji Yamamoto and Masako Waguri and Akihisa Imagawa and Seiko Tamura and Mitsuo Inada},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 5},
  pages={2313-22}
}
We examined pancreas biopsy specimens from 18 newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients to elucidate the mechanism underlying beta cell destruction. Pancreas islets were seen in all patients and insulitis in eight patients. Infiltrating mononuclear cells consisted of CD4+T, CD8+T, B lymphocytes, and macrophages. Among them, CD8+T lymphocytes were predominant and macrophages followed. The expression of MHC class I antigens was increased in islet and endothelial cells in… CONTINUE READING

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