Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome

  title={Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome},
  author={Timoth{\'e}e Lenglet and Julien Haroche and Aur{\'e}lie Schnuriger and Thierry Maisonobe and Karine Viala and Yanne Michel and F Chelbi and David Grabli and Paul Seror and Antoine Garbarg-Chenon and Zahir Amoura and Pierre Bouche},
  journal={Journal of Neurology},
To describe the characteristics of peripheral neuropathy related to acute parvovirus B19 (B19V) infection. We reviewed clinical, electrophysiological and histological data of three patients with peripheral neuropathy and positive B19V detection (IgG, IgM and PCR) compatible with acute infection. The neuropathy fulfilled criteria for mononeuropathy multiplex (MM). It could be preceded by or concurrent with a limited purpuric eruption, but systemic manifestations were absent. The first… 
Extra-haematological manifestations related to human parvovirus B19 infection: retrospective study in 25 adults
Although the prognosis is good, IVIg therapy should be discussed in patients with peripheral nerve involvement, and its efficacy should be further investigated in prospective studies.
A Parsonage-Turner Syndrome secondary to Parvovirus B19 infection
A 37-year-old man with neuralgic amyotrophy (Parsonage-Turner syndrome) caused by Parvovirus B19 infection is described.
Neurological aspects of human parvovirus B19 infection: a systematic review
B19 should be included in differential diagnosis of encephalitic syndromes of unknown etiology in all age groups, and diagnosis should rely on investigation of anti‐B19 IgM antibodies and detection of B19 DNA in serum or CSF.
The neuropathies of vasculitis.
Vasculitis related to viral and other microbial agents.
  • G. Teng, W. Chatham
  • Medicine, Biology
    Best practice & research. Clinical rheumatology
  • 2015
Clinical impact & pathogenic mechanisms of human parvovirus B19: A multiorgan disease inflictor incognito
Novel clinical associations of B19V observed were amegakaryocytic thrombocytopaenia, myositis and non-occlusive ischaemic gangrene of bowel, and numerous reports on B 19V infections substantiate a causal role in multiorgan diseases.
Parvovirus B19 Infection in Children With Arterial Ischemic Stroke
Using MassTag–polymerase chain reaction, parvovirus B19—a virus known to infect erythrocytes and endothelial cells—in some cases of childhood arterial ischemic stroke is detected, which can generate new, testable hypotheses about childhood stroke pathogenesis.
Paraneoplastic Mononeuritis Multiplex as a Presenting Feature of Adenocarcinoma of the Lung
A patient presenting with bilateral asymmetrical sensorimotor polyneuropathy who was diagnosed with adenocarcinoma of the lung is reported.


Vasculitic Neuropathies: An Update
Long-term immunosuppressive therapy is required in most cases of vasculitic neuropathy, and high-dose prednisone combined with intravenous pulse or oral daily cyclophosphamide is standard initial therapy.
Neurologic manifestations associated with parvovirus B19 infection.
Eighty-one cases of neurologic disease, including encephalitis, meningitis, stroke, and peripheral neuropathy, that were associated with parvovirus B19 infection were reviewed and no differences in the prevalence of sequealae were noted.
Treatment of parvovirus B19-associated polyarteritis nodosa with intravenous immune globulin.
A patient who had polyarteritis nodosa associated with parvovirus B19 infection that regressed completely with intravenous immune globulin therapy is described.
Primary and secondary vasculitic neuropathy
In all instances symptomatic vasculitis requires corticosteroid to control the inflammatory process and prevent further ischemic nerve lesions.
Acute bilateral carpal tunnel syndrome associated with human parvovirus B19 infection.
Three cases of acute bilateral carpal tunnel syndrome associated with parvovirus B19 infection are described as evidenced by serological data and, in one case, by detection of parvoterrorism B19 DNA in blood with use of PCR.
Clinical aspects of parvovirus B19 infection
Parvovirus B19 is a significant human pathogen that causes a wide spectrum of clinical complications ranging from mild, self‐limiting erythema infectiosum in immunocompetent children to lethal
Parvovirus B19 clearance from peripheral blood after acute infection.
One patient showed a persistent infection associated with chronic arthritis and was positive for B19 DNA for 1 year without clearance of the virus, followed after acute infection to determine how long the virus is present in blood, even at low titer.
Persistent B19 infection in immunocompetent individuals: implications for transfusion safety.
Results demonstrate that persistence of low levels of B19 DNA suggested by cross-sectional studies is frequent in multitransfused patients and that the virus may remain detectable several years after infection in nonimmunodeficient individuals.