Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12.

  title={Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12.},
  author={Christopher T. Veldkamp and Joshua J Ziarek and Jidong Su and Harihar Basnet and Richard Lennertz and Joshua J. Weiner and Francis C Peterson and John E Baker and Brian F Volkman},
  journal={Protein science : a publication of the Protein Society},
  volume={18 7},
The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) directs leukocyte migration, stem cell homing, and cancer metastasis through activation of CXCR4, which is also a coreceptor for T-tropic HIV-1. Recently, SDF-1 was shown to play a protective role after myocardial infarction, and the protein is a candidate for development of new anti-ischemic compounds. SDF-1 is monomeric at nanomolar concentrations but binding partners promote self-association at higher concentrations to form a typical… CONTINUE READING


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