Monomeric Fc fusions: impact on pharmacokinetic and biological activity of protein therapeutics.

@article{Dumont2006MonomericFF,
  title={Monomeric Fc fusions: impact on pharmacokinetic and biological activity of protein therapeutics.},
  author={Jennifer A Dumont and Susan C. Low and Robert T. Peters and Alan J. Bitonti},
  journal={BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy},
  year={2006},
  volume={20 3},
  pages={151-60}
}
The delivery of therapeutic proteins by noninvasive routes of administration has been a challenging goal, hence current modes of delivery generally require injections. However, we have recently shown that a naturally occurring receptor, the neonatal Fc receptor (FcRn) can be utilized to carry aerosolized therapeutic proteins conjugated to a portion of its respective ligand (Fc domain of immunoglobulin G) across epithelial cells of the lung to effectively deliver biologically active molecules to… CONTINUE READING