Monolithic Encapsulation of Implantable Neuroprosthetic Devices Using Liquid Crystal Polymers

@article{Lee2011MonolithicEO,
  title={Monolithic Encapsulation of Implantable Neuroprosthetic Devices Using Liquid Crystal Polymers},
  author={Seungwoo Lee and K. Min and Joonsoo Jeong and Junghoon Kim and S. Kim},
  journal={IEEE Transactions on Biomedical Engineering},
  year={2011},
  volume={58},
  pages={2255-2263}
}
  • Seungwoo Lee, K. Min, +2 authors S. Kim
  • Published 2011
  • Materials Science, Computer Science
  • IEEE Transactions on Biomedical Engineering
Flexible polymers have gained much attention in the development of low cost, magnetic resonance compatible, and nonfragile implantable medical devices. [...] Key Method This platform offers monolithic encapsulation by fusion bonding of the hemispherical LCP package lids and LCP-based microelectrode arrays. The package lids were fabricated by thermoforming of the LCP films to provide the desired shape and size for encasing the electronic components and wireless telemetry coils. Fusion-bonded LCP encapsulations…Expand
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References

SHOWING 1-10 OF 47 REFERENCES
Development of microelectrode arrays for artificial retinal implants using liquid crystal polymers.
TLDR
LCP-based flexible microelectrode arrays can be successfully applied as retinal prostheses and demonstrate that such electrode arrays are safe, biocompatible, and mechanically stable and that they can be effective as part of a chronic retinal implant system. Expand
Flexible Nerve Stimulation Electrode With Iridium Oxide Sputtered on Liquid Crystal Polymer
TLDR
Electrochemical analysis and results indicate that sputtered iridium oxide films on LCP could become the method of choice for flexible substrate nerve electrodes, along with the flexible, chemically inert, and biocompatible substrate. Expand
Feasibility of microelectrode array (MEA) based on silicone-polyimide hybrid for retina prosthesis.
TLDR
In vivo testing indicated that this silicone-polyimide hybrid microelectrode array showed moderate physical properties, which are suitable for in vivo application, and Appropriate pretreatment before hybridization improved electrode stability. Expand
Fabrication and Characterization of Flexible, Microfabricated Neural Electrode Arrays Made from Liquid Crystal Polymer and Polynorbornene
This paper reports the development of flexible, neural electrode arrays made from liquid crystal polymer (LCP) and a polynorbornene (PNB) known by its trade name AvatrelTM. Each array consists of aExpand
Liquid crystal polymer for RF MEMS packaging
We have developed a Liquid Crystal Polymer (LCP) encapsulation technology for RF MEMS. The RF MEMS devices are flip-chip interconnected on 50 ohm microstrip transmission line on an alumina substrate.Expand
Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator
TLDR
A wirelessly operated, minimally invasive retinal prosthesis was developed for preclinical chronic implantation studies in Yucatan minipig models and verified both in vitro and in vivo in three pigs for more than seven months. Expand
An Optically Powered Single-Channel Stimulation Implant as Test System for Chronic Biocompatibility and Biostability of Miniaturized Retinal Vision Prostheses
TLDR
A microsystem based microimplant with an optically powered single-channel stimulator was designed and developed as test system for an epi-retinal vision implant and indicated the feasibility of the system approach for chronic use. Expand
Neural signal recording using microelectrode arrays fabricated on liquid crystal polymer material
Abstract Microelectrode arrays have been developed for simultaneous multi-channel recordings from nervous systems, typically using silicon substrates. However, it has been known that it is difficultExpand
LCP injection molded packages - keys to JEDEC 1 performance
  • R. Ross
  • Materials Science
  • 2004 Proceedings. 54th Electronic Components and Technology Conference (IEEE Cat. No.04CH37546)
  • 2004
The LCP (liquid crystal polymer) is a class of high performance, high temperature thermoplastic polymers which can be formulated to provide injection molding compounds having properties uniquelyExpand
A hermetic glass-silicon micropackage with high-density on-chip feedthroughs for sensors and actuators
This paper describes the development of a hermetic micropackage with high-density on-chip feedthroughs for sensor and actuator applications. The packaging technique uses low-temperature (320/splExpand
...
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3
4
5
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