Monolingual and bilingual language networks in healthy subjects using functional MRI and graph theory

  title={Monolingual and bilingual language networks in healthy subjects using functional MRI and graph theory},
  author={Qiongge Li and Luca Pasquini and Gino Del Ferraro and Madeleine N Gene and Kyung K. Peck and Hern{\'a}n A. Makse and Andrei I. Holodny},
  journal={Scientific Reports},
Bilingualism requires control of multiple language systems, and may lead to architectural differences in language networks obtained from clinical fMRI tasks. Emerging connectivity metrics such as k-core may capture these differences, highlighting crucial network components based on resiliency. We investigated the influence of bilingualism on clinical fMRI language tasks and characterized bilingual networks using connectivity metrics to provide a patient care benchmark. Sixteen right-handed… 
2 Citations
Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications
When the language-dominant hemisphere is damaged by a focal lesion, the brain may reorganize the language network through functional and structural changes known as adaptive plasticity. Adaptive
Spatial Stability of Functional Networks: A Measure to Assess the Robustness of Graph-Theoretical Metrics to Spatial Errors Related to Brain Parcellation
There is growing interest in studying human brain connectivity and in modelling the brain functional structure as a network. Brain network creation requires parcellation of the cerebral cortex to


Core language brain network for fMRI language task used in clinical applications
This work investigates the functional architecture of 20 healthy individuals performing a language task designed for clinical purposes and uncovers a common architecture persistent across all subjects under study, that is called “core” network, which involves Broca’s area, Wernicke's area, the premotor area, and the pre-supplementary motor area.
Functional Connectivity Reveals Which Language the “Control Regions” Control during Bilingual Production
The findings suggest that the dACC monitors and supports the processing of the target language, and that the Lcaudate controls the selection of the less accessible language in bilinguals.
Lifelong Bilingualism Maintains White Matter Integrity in Older Adults
Previous research has shown that bilingual speakers have higher levels of cognitive control than comparable monolinguals, especially at older ages. The present study investigates a possible neural
Role of Semantic Paradigms for Optimization of Language Mapping in Clinical fMRI Studies
The combination of Silent Word Generation and ≥1 visual semantic paradigm, such as Sentence Completion and Noun-Verb Association, is adequate to determine language localization and lateralization; Noun’s Verb Association has the additional advantage of objective monitoring of patient performance.
Neurolinguistics: Structure, Function, and Connectivity in the Bilingual Brain
The plethora of findings that relate to the structural, functional, and connective changes in the brain that ensue from bilingualism are compiled and interpreted.
Presurgical language fMRI: Mapping of six critical regions
Initial validation of a novel, clinician‐based approach to localizing language cortex is provided and clinical fMRI is superior when analyzed by an experienced clinician and that when fMRI data is of low quality judgments of laterality are unreliable and should be withheld.
Functional Translocation of Broca's Area in a Low-Grade Left Frontal Glioma: Graph Theory Reveals the Novel, Adaptive Network Connectivity
We describe frontal language reorganization in a 50–60 year-old right-handed patient with a low-grade left frontotemporal insular glioma. Pre-operative fMRI revealed robust activation in the left
Lexical-Semantic Search Under Different Covert Verbal Fluency Tasks: An fMRI Study
Study results support the hypothesis of overlapping, as well as distinct, neural networks for covert word generation when guided by different linguistic cues and suggest that retrieval-related search and post-retrieval control processes that subserve verbal fluency reverberates across distinct functional networks as determined by respective task demands.