Monolayer culture systems with respiratory epithelial cells for evaluation of bacterial invasiveness.

@article{Hirakata2010MonolayerCS,
  title={Monolayer culture systems with respiratory epithelial cells for evaluation of bacterial invasiveness.},
  author={Yoshimi Hirakata and Hisakazu Yano and Kazuaki Arai and Shiro Endo and Hajime Kanamori and Tetsuji Aoyagi and Ayako Hirotani and Miho Kitagawa and Masumitsu Hatta and Natsuo Yamamoto and Hiroyuki Kunishima and Kazuyoshi Kawakami and Mitsuo Kaku},
  journal={The Tohoku journal of experimental medicine},
  year={2010},
  volume={220 1},
  pages={
          15-9
        }
}
Pseudomonas (P.) aeruginosa is a major opportunistic pathogen especially in immunocompromised patients. To evaluate the invasiveness of respiratory pathogens, we developed monolayer culture systems and examined the degree of invasion by P. aeruginosa and invasive Salmonella (S.) typhimurium strains using human respiratory cell lines: A549 (derived from lung cancer), BEAS-2B (normal bronchial epithelium), and Calu-3 (pleural effusion of a patient with adenocarcinoma of the lung). Cells were… CONTINUE READING

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