Monokine production by microglial cell clones.

  title={Monokine production by microglial cell clones.},
  author={M Francesca Righi and Lucia Mori and Gennaro De Libero and Marina Sironi and Andrea Biondi and Alberto Mantovani and Silvia Donini and Paola Ricciardi-Castagnoli},
  journal={European journal of immunology},
  volume={19 8},
Cytokines have been suggested to act as intermediates between the immune and the central nervous system, but little is known about the type of cells synthesizing them in the brain. We have immortalized with oncogenic retroviruses primary brain cell cultures from mouse embryos and have generated clones of microglial cells that have been characterized. Three of the clones studied produce interleukin 1 (IL 1); IL 6 and tumor necrosis factor-alpha as assessed by biological assays and by Northern… CONTINUE READING

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