Monokine induced by interferon-gamma is induced by receptor activator of nuclear factor kappa B ligand and is involved in osteoclast adhesion and migration.

@article{Kwak2005MonokineIB,
  title={Monokine induced by interferon-gamma is induced by receptor activator of nuclear factor kappa B ligand and is involved in osteoclast adhesion and migration.},
  author={Han Bok Kwak and Soo Woong Lee and Hye Mi Jin and Hyunil Ha and Sang Ho Lee and Sunao Takeshita and Sakae Tanaka and Hyun-Man Kim and Hong-Hee Kim and Zang Hee Lee},
  journal={Blood},
  year={2005},
  volume={105 7},
  pages={2963-9}
}
Bone remodeling is accompanied by the differentiation of osteoclasts from the monocyte/macrophage lineage of hematopoietic cells. The osteoclast differentiation process requires receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL), which causes complex changes in the expression of various genes. In a cDNA microarray study to identify genes targeted by RANKL, we found that monokine induced by the interferon-gamma (IFN-gamma) (MIG) gene was up-regulated in osteoclast precursor… CONTINUE READING