• Corpus ID: 12111134

Monograph α-Lipoic Acid Synonyms : Thioctic acid

  title={Monograph $\alpha$-Lipoic Acid Synonyms : Thioctic acid},
  • Biology, Medicine
Monograph α α α α α-Lipoic Acid Synonyms: Thioctic acid; 2-dithiolane-3 penatanoic acid; 1,2-dithiolane-3 valeric acid Pharmacokinetics α-Lipoic acid (ALA) can be synthesized by both animals and humans. 1 It seems to be readily absorbed from an oral dose and converts easily to its reduced form, dihydrolipoic acid (DHLA), in many tissues of the body. An in vitro study 2 indicated that normal mam-malian cells appear to be capable of taking up α-lipoic acid and reducing it to DHLA. The effects of… 



Alpha-lipoic acid is an effective inhibitor of human immuno-deficiency virus (HIV-1) replication

Trypan blue staining revealed no toxic effects of alpha-lipoic acids on peripheral blood mononuclear cells and T-cell lines even in concentrations of ≥70 μg/ml, and the inclusion ofalpha- Lipoic acid into chemotherapy trials in combination with zidovudine is proposed.

Reversal of Selective Toxicity of (−)-α-Lipoic Acid by Thiamine in Thiamine-deficient Rats

The results obtained from the use of the racemic form of lipoic acid could not reveal whether both or one of the isomers had been responsible for the toxic effects in the deficient animals, and could not be related to the depletion of theThiamine reserves present in the organs of thiamine-deficient animals.

Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo.

In vivo experiments with whole body irradiation in mice revealed that the number of surviving animals was doubled at a dose of 16 mg lipoic acid/kg, which corresponds with protection from irradiation damage in these in vitro studies.

Stimulation of Glucose Uptake by the Natural Coenzyme α-Lipoic Acid/Thioctic Acid: Participation of Elements of the Insulin Signaling Pathway

Evidence that a physiologically relevant compound can stimulate glucose transport via the insulin signaling pathway is found, as thioctic acid stimulates basal glucose transport and has a positive effect on insulin-stimulated glucose uptake.

Dihydrolipoic acid prevents hypoxic/reoxygenation and peroxidative damage in rat heart mitochondria.

Fluorescence anisotropy (r) was determined in hypoxic/reoxygenating rat heart mitochondria by means of 1,6-diphenyl-1,3,5-hexatriene. During hypoxia, values for r increased, indicating a rigidified