Monogenic causes of inflammatory disease in rheumatology.

  title={Monogenic causes of inflammatory disease in rheumatology.},
  author={James W. Verbsky},
  journal={Current opinion in rheumatology},
  volume={24 5},
PURPOSE OF REVIEW To review the single-gene defects that can mimic rheumatologic diseases. RECENT FINDINGS Monogenic disorders can cause a variety of diseases that may be seen by a rheumatologist. Many of these illnesses present with recurrent episodes of arthritis, rash, fever and inflammation, and serositis. Recent discoveries have defined inflammatory diseases due to mutations in the IL-1 and IL-36 receptor antagonists, as well as the immunoproteosome. Further study of well defined… CONTINUE READING