Monogenic autoinflammatory diseases: Cytokinopathies.

  title={Monogenic autoinflammatory diseases: Cytokinopathies.},
  author={Fiona Moghaddas and Seth L Masters},
  volume={74 2},
Rapid advances in genetics are providing unprecedented insight into functions of the innate immune system with identification of the mutations that cause monogenic autoinflammatory disease. Cytokine antagonism is profoundly effective in a subset of these conditions, particularly those associated with increased interleukin-1 (IL-1) activity, the inflammasomopathies. These include syndromes where the production of IL-1 is increased by mutation of innate immune sensors such as NLRP3, upstream… CONTINUE READING