Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants

@article{Einav2017MonodWymanChangeuxAO,
  title={Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants},
  author={Tal Einav and Rob Phillips},
  journal={bioRxiv},
  year={2017}
}
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration ([EC50]), and effective Hill coefficient, and explore the full spectrum of phenotypes that are accessible through mutations. Specifically, we consider mutations in the channel pore of nicotinic acetylcholine… 
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