Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.

@article{Klimchenko2011MonocyticCD,
  title={Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.},
  author={Olena Klimchenko and Antonio di Stefano and Birgit Geoerger and Sofiane Hamidi and Paule Opolon and Thomas Robert and M{\'e}lanie Routhier and Jamel El-Benna and Anne-lise Delezoide and Siham Boukour and Bernadette Lescure and {\'E}ric Solary and William Vainchenker and Francoise Norol},
  journal={Blood},
  year={2011},
  volume={117 11},
  pages={3065-75}
}
The early emergence of macrophages and their large pattern of tissue distribution during development suggest that they may play a critical role in the initial steps of embryogenesis. In the present study, we show that monocytic cells derived from human embryonic stem cells (hESCs) and from fetal liver follow a differentiation pathway different to that of adult cells, leading to specific functions. Embryonic and fetal monocytic cells differentiated from a CD14(low)CD16(-) precursor to form CD14… CONTINUE READING
Highly Cited
This paper has 56 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

57 Citations

01020'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 57 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Similar Papers

Loading similar papers…