Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

@inproceedings{Ouzounova2017MonocyticAG,
  title={Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade},
  author={Maria D. Ouzounova and Eunmi Lee and Raziye Piranlioglu and Abdeljabar El Andaloussi and Ravindra Kolhe and Mehmet F Demirci and Daniela Marasco and Iskander Asm and Ahmed Chadli and Khaled A. Hassan and Muthusamy Thangaraju and Gang Zhou and Ali S. Arbab and John K Cowell and Hasan Korkaya},
  booktitle={Nature communications},
  year={2017}
}
It is widely accepted that dynamic and reversible tumour cell plasticity is required for metastasis, however, in vivo steps and molecular mechanisms are poorly elucidated. We demonstrate here that monocytic (mMDSC) and granulocytic (gMDSC) subsets of myeloid-derived suppressor cells infiltrate in the primary tumour and distant organs with different time kinetics and regulate spatiotemporal tumour plasticity. Using co-culture experiments and mouse transcriptome analyses in syngeneic mouse models… CONTINUE READING
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