Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1.

@article{Mewhort2016MonocytesIH,
  title={Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1.},
  author={Holly E. M. Mewhort and Brodie D Lipon and Daniyil A. Svystonyuk and Guoqi Teng and David G. Guzzardi and Cl{\'a}udia L{\'u}cia da Silva and Voon Wee Yong and Paul W M Fedak},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2016},
  volume={310 6},
  pages={
          H716-24
        }
}
Following myocardial infarction (MI), cardiac myofibroblasts remodel the extracellular matrix (ECM), preventing mechanical complications. However, prolonged myofibroblast activity leads to dysregulation of the ECM, maladaptive remodeling, fibrosis, and heart failure (HF). Chronic inflammation is believed to drive persistent myofibroblast activity; however, the mechanisms are unclear. We assessed the influence of peripheral blood monocytes on human cardiac myofibroblast activity in a three… CONTINUE READING

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