Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis.

@article{Rana2018MonocytesIR,
  title={Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis.},
  author={Amit Kumar Rana and Yang Li and Qiujie Dang and Fan Yang},
  journal={International immunopharmacology},
  year={2018},
  volume={65},
  pages={
          348-359
        }
}
  • A. Rana, Yang Li, Fan Yang
  • Published 23 October 2018
  • Biology, Medicine
  • International immunopharmacology

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TLDR
CCR9 expression by monocytes is increased in RA and CCL25 may be involved in the differentiation of monocytes to macrophages particularly in RA.

Blood monocyte activation in rheumatoid arthritis: increased monocyte adhesiveness, integrin expression, and cytokine release

TLDR
In this study, blood monocytes from RA patients exhibited features of activation related to cell adhesion, and production of extracellular IL‐1β and IL‐6 by RA monocytes was significantly enhanced compared with monocyte from normal subjects.

Recruitment of CD16+ monocytes into synovial tissues is mediated by fractalkine and CX3CR1 in rheumatoid arthritis patients.

TLDR
The results suggest that FKN might preferentially mediate migration and recruitment of CD16+ monocytes, and might contribute to synovial tissue inflammation.

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The findings suggest that the cytokine milieu of the synovial fluid shapes the unique features ofsynovial monocytes as well as their cardinal role in shaping inflammatory T-cell responses in RA.

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TLDR
The results suggest that peripheral blood monocytes consist of two functionally heterogeneous subsets with distinct responses to RANKL, and seem to originate from CD16- monocytes, and integrin β3 is necessary for osteoclastogenesis.

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TLDR
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CD56+ monocytes have a dysregulated cytokine response to lipopolysaccharide and accumulate in rheumatoid arthritis and immunosenescence

TLDR
The CD14bright/CD56+ monocyte subset is expanded in aging individuals as well as in patients with RA, and the elimination of those cells in Patients with a good response towards TNF inhibiting agents indicates a possible contribution of those monocytes in the inflammatory response in RA.

SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis

TLDR
SIRT1 appears to inhibit monocyte to macrophage differentiation by suppressing PU.1 phosphorylation and inflammatory signaling, which suggests SIRT1 plays a critical role in the regulation of synovial inflammation in RA.
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