Monocytes from mobilized stem cells inhibit T cell function.

  title={Monocytes from mobilized stem cells inhibit T cell function.},
  author={Kazuko Ino and Rakesh K. Singh and James E Talmadge},
  journal={Journal of leukocyte biology},
  volume={61 5},
Granulocyte-macrophage colony-stimulating factor, mobilized peripheral blood stem cell (PSC) products, and peripheral blood leukocytes posttransplantation contain cells that cause allogeneic and autologous T cell apoptosis. Isolation and characterization of these cells demonstrated that they were low-density (Percoll fractionation) CD14+ monocytes. T cells in PSC products have a depressed phytohemagglutinin (PHA) mitogenic response; however, purified CD4+ or CD8+ T cells exhibit a statistically… CONTINUE READING