Monocytes from Sjögren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis.

@article{Hauk2014MonocytesFS,
  title={Monocytes from Sj{\"o}gren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis.},
  author={Vanesa Hauk and Laura Fraccaroli and Esteban Nicol{\'a}s Grasso and Alicia Eimon and Rosanna E Ramhorst and Osvaldo Hubscher and Claudia P{\'e}rez Leir{\'o}s},
  journal={Clinical and experimental immunology},
  year={2014},
  volume={177 3},
  pages={662-70}
}
Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by salivary and lacrimal gland dysfunction. Clinical observations and results from animal models of SS support the role of aberrant epithelial cell apoptosis and immune homeostasis loss in the glands as triggering factors for the autoimmune response. Vasoactive intestinal peptide (VIP) promotes potent anti-inflammatory effects in several inflammatory and autoimmune disease models, including the non-obese diabetic (NOD) mouse… CONTINUE READING
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