Monocytes are the major producers of interleukin-1 beta in an ex vivo model of local cytokine production.


Interleukin-1 beta (IL-1 beta) is an early proinflammatory cytokine with multiple effects. Several cells are capable of synthesizing this cytokine, but little is understood about which cell produces IL-1 in disease states. We examined the cellular source of IL-1 in lipopolysaccharide (LPS)-stimulated human whole blood. Cytospin preparations of leukocytes… (More)