Monocyte-suppressing effect of high-dose metformin in fenofibrate-treated patients with impaired glucose tolerance.

@article{Krysiak2013MonocytesuppressingEO,
  title={Monocyte-suppressing effect of high-dose metformin in fenofibrate-treated patients with impaired glucose tolerance.},
  author={Robert G Krysiak and Anna Gdula-Dymek and Bogusław Okopień},
  journal={Pharmacological reports : PR},
  year={2013},
  volume={65 5},
  pages={1311-6}
}
BACKGROUND Fibrates were found to reduce cytokine release and low-grade inflammation in patients with impaired glucose tolerance. The aim of this study was to investigate whether these effects of fibrates may be potentiated by metformin treatment. METHODS The study included 43 patients with isolated impaired glucose tolerance and normal plasma lipids who had been treated for at least 6 months with micronized fenofibrate (200 mg daily). These subjects were randomly assigned to 12 weeks… CONTINUE READING

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