Monocyte subpopulations and cardiovascular risk in chronic kidney disease

@article{Heine2012MonocyteSA,
  title={Monocyte subpopulations and cardiovascular risk in chronic kidney disease},
  author={Gunnar Henrik Heine and Alberto Ortiz and Ziad A Massy and Bengt Lindholm and Andrzej Wiȩcek and Alberto Mart{\'i}nez-Castelao and Adrian Constantin Covic and David J. A. Goldsmith and G{\"u}ltekin S{\"u}leymanlar and G{\'e}rard Michel London and Gianfranco Parati and Rosa Sicari and Carmine Zoccali and Danilo Fliser},
  journal={Nature Reviews Nephrology},
  year={2012},
  volume={8},
  pages={362-369}
}
Chronic microinflammation and its cellular hallmark, monocyte activation, contribute substantially to the tremendous burden of cardiovascular disease (CVD) in patients with chronic kidney diseases (CKD). Monocyte heterogeneity is widely acknowledged. Cell-surface expression of CD14 and CD16 defines three functionally and phenotypically distinct subsets of monocytes: classical (CD14++CD16−) monocytes, intermediate (CD14++CD16+) monocytes, and nonclassical (CD14+CD16++) monocytes. A growing body… CONTINUE READING
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