Monocyte response to Th1 stimulation and effector function toward human mesangial cells are not impaired in patients with lupus nephritis.

@article{Kuroiwa2003MonocyteRT,
  title={Monocyte response to Th1 stimulation and effector function toward human mesangial cells are not impaired in patients with lupus nephritis.},
  author={Takashi Kuroiwa and Ryan Jon Schlimgen and Gabor G. Illei and Dimitrios T. Boumpas},
  journal={Clinical immunology},
  year={2003},
  volume={106 1},
  pages={65-72}
}
Monocytes/macrophages activated by Th1 stimulation such as interferon-gamma (IFN-gamma) and CD40 ligand (CD40L) infiltrate the kidney and play a critical role in the progression of lupus nephritis (LN). We examined the monocyte response to Th1 stimulation and their effector function toward activating renal resident cells in patients with LN. Following stimulation with IFN-gamma granulocyte macrophage-colony stimulating factor (GM-CSF)/recombinant CD40L the production of tumor necrosis factor… CONTINUE READING