Monocyte phosphodiesterase abnormalities and dysregulation of lymphocyte function in atopic dermatitis.

@article{Hanifin1995MonocytePA,
  title={Monocyte phosphodiesterase abnormalities and dysregulation of lymphocyte function in atopic dermatitis.},
  author={Jon M. Hanifin and Sye-Min Chan},
  journal={The Journal of investigative dermatology},
  year={1995},
  volume={105 1 Suppl},
  pages={84S-88S}
}
The immunologic aberrations associated with atopic dermatitis include the paradox of reduced cell-mediated immune responses in the setting of increased cell-mediated immunity features that resemble allergic contact dermatitis. In this review, we present evidence that abnormalities in monocytes and Langerhans cells alter the function of T-helper-cell subpopulations to cause the immunologic defects associated with atopic dermatitis. Increased monocyte prostaglandin E2 production inhibits Th1… CONTINUE READING

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