Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage.

@article{Kim2010MonocyteHU,
  title={Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage.},
  author={W Y Kim and Yue Sun and Hien Thi Thu Do and Patrick J. Autissier and Elkan F. Halpern and Michael J. Piatak and Jeffrey D Lifson and Tricia H. Burdo and Michael S. McGrath and Kenneth Williams},
  journal={Journal of leukocyte biology},
  year={2010},
  volume={87 4},
  pages={557-67}
}
Infection by HIV is associated with the expansion of monocytes expressing CD16 antigens, but the significance of this in HIV pathogenesis is largely unknown. In rhesus macaques, at least three subpopulations of blood monocytes were identified based on their expression of CD14 and CD16: CD14(high)CD16(-), CD14(high)CD16(low), and CD14(low)CD16(high). The phenotypes and functions of these subpopulations, including CD16(+) monocytes, were investigated in normal, uninfected rhesus macaques and… CONTINUE READING
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