Monocyte esterase deficiency in gastrointestinal cancer.

  title={Monocyte esterase deficiency in gastrointestinal cancer.},
  author={Geraldine M Markey and Robert C. Curry and D Swain and T. C. M. Morris and James A. McCormick and H. Denis Alexander and Schmitt Edgar},
  journal={Journal of Clinical Pathology},
  pages={529 - 532}
AIM--To substantiate the high incidence of monocyte esterase deficiency (MED) in gastrointestinal carcinoma already reported in a small group of patients; to compare the clinical findings in esterase deficient and esterase positive patients. METHODS--Peripheral blood smears (n = 22) or cytocentrifuge preparations (n = 52) of mononuclear cells from the peripheral blood of patients with gastrointestinal carcinoma were stained by the non-specific esterase stain (pH 5.8) using a batch technique… 

Organophosphates and monocyte esterase deficiency.

Current or recent exposure to organophosphorus is not the cause of MED, and no significant difference was found between the enzyme activities of the monocyte esterase deficient group and the control group for any of the esterases investigated.

Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture.

Esterified ALAs are new and promising drugs for use in photochemotherapy of cancer and high-performance liquid chromatography and fluorescence microscopic studies indicated that esterification of ALA has neither impact on the fluorescing porphyrin species formed nor impact on their intracellular localization.

Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX.

Two zinc-bis(dipicolylamine) (ZnBDPA) compounds were evaluated for their ability to promote uptake of 5-ALA into Chinese Hamster Ovary cells and produce protoporphyrin IX, and one of the compounds was found to be quite effective.

Carboxylesterase 1 (Ces1): from monocyte marker to major player

  • G. Markey
  • Biology
    Journal of Clinical Pathology
  • 2010
Monocyte esterase/Ces 1 involvement in the fields of histochemistry, haematology, toxicology, pharmacology, therapeutics, and tumour cell killing, immune surveillance and malignant disease, is briefly described.

Relationship of protoporphyrin IX synthesis to photodynamic effects by 5‐aminolaevulinic acid and its esters on various cell lines derived from the skin

ALA and its esters act as precursors to the fluorescent photosensitizer protoporphyrin IX (PpIX) in photodynamic therapy (PDT) and induce PpIX synthesis and photodynamic effects in cell lines derived from the skin.

Depletion of non specific esterase activity in the colonic mucosa of patients with ulcerative colitis

This work investigates the presence and localization of NSE, in the normal and inflamed human colonic mucosa.

Quantitative deficiency of monocyte‐specific esterase (MSE) mRNA in monocyte esterase deficiency (MED)

Findings show that deficiency of monocyte esterase activity in MED is not as a result of the presence of inactive isoenzymes and may be owing to an abnormality in the regulation of mRNA production.

Biology of Monocyte-Specific Esterase

A more thorough understanding of the in vivo function of function of this truly unique enzyme should be helped by characterizing the signals anti signal transduction mechanisms which lead to MSE expression.



Monocyte esterase deficiency in malignant neoplasia.

It is suggested that the reason for the increased prevalence of the anomaly in these disorders might be that the diminution of esterase activity has a role in their development.

Monocyte esterase? A factor involved in the pathogenesis of lymphoproliferative neoplasia.

It is postulate that the presence of the anomaly may be either a factor predisposing to the development of the NHL or CLL or a factor indicating a predisposition to these disorders.

Lactoferrin inducible monocyte cytotoxicity defective in esterase deficient monocytes

Esterase positive monocytes responded to lactoferrin stimulation by a five‐fold increase in cytotoxicity whereas deficient monocytes failed to produce any response.

The relevance of α‐naphthyl acetate esterases to various monocyte functions

Investigations show that monocyte specific αNA esterases are involved in the spontaneous cytotoxicity of monocytes toward tumour cells.

Organophosphate exposure inhibits non-specific esterase staining in human blood monocytes.

Results showed a decrease in nonspecific esterase staining with the Technicon D-90, and no significant effect on monocyte numbers or ester enzyme positivity was found with the other three techniques.

Whole blood staining in suspension for nonspecific esterase and alkaline phosphatase analyzed with a Technicon H-1.

A semiautomated method using whole blood that could be employed on a large scale for hematology laboratory applications, including toxicology studies, measurement of neutrophil left shift, and cytochemical classification of myeloid leukemias is developed.

Inhibition of esterase activity and an undercounting of circulating monocytes in a population of production workers.

  • M. S. LevineN. Fox W. Rutten
  • Medicine
    Journal of occupational medicine. : official publication of the Industrial Medical Association
  • 1986
A cross-sectional review of routine employee health status examinations has identified an undercounting of circulating monocytes associated with an inhibition of a surface monocyte ester enzyme, alpha-naphthyl butyrate esterase, associated with a organophosphate used in the production process.

Heredofamilial deficiency of monocyte esterase in patients with rheumatoid arthritis.

Deficiency of the monocyte ectoenzyme non-specific esterase is described in a heredofamilial pattern in four patients with rheumatoid arthritis. No association with HLA status or rheumatoid factor