Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

@article{Serbina2006MonocyteEF,
  title={Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2},
  author={Natalya V. Serbina and Eric G. Pamer},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={311-317}
}
Monocytes recruited to tissues mediate defense against microbes or contribute to inflammatory diseases. Regulation of the number of circulating monocytes thus has implications for disease pathogenesis. However, the mechanisms controlling monocyte emigration from the bone marrow niche where they are generated remain undefined. We demonstrate here that the chemokine receptor CCR2 was required for emigration of Ly6Chi monocytes from bone marrow. Ccr2−/− mice had fewer circulating Ly6Chi monocytes… CONTINUE READING
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