Monocyte dysfunction as a previously unrecognized pathophysiological mechanism in ApoE-/- mice contributing to impaired arteriogenesis.

@article{Tchaikovski2015MonocyteDA,
  title={Monocyte dysfunction as a previously unrecognized pathophysiological mechanism in ApoE-/- mice contributing to impaired arteriogenesis.},
  author={Vadim Tchaikovski and Svetlana N. Tchaikovski and Serv{\'e} J F Olieslagers and Johannes Waltenberger},
  journal={International journal of cardiology},
  year={2015},
  volume={190},
  pages={
          214-6
        }
}
Hyperlipidemia(HL)isamajorcardiovascularriskfactorpromotingatherogenesis leadingto coronaryandperipheralartery disease.Collat-eralvessel development, a crucial compensatorymechanismin periph-eral artery disease, is negatively influenced by HL [1]. Monocytes andtissue-resident macrophages accelerate both atherogenesis andarteriogenesis by supplying growth factors, cytokines and proteolyticenzymes [2]. The decreased monocyte/macrophage accumulationaround growing collateral vessels in HL is… CONTINUE READING
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