Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily

@article{Modi2004MonocytederivedNC,
  title={Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily},
  author={William Stephen Modi and M. Dean and H{\'e}ctor N. Seu{\'a}nez and Naofumi Mukaida and Kouji Matsushima and Stephen J. O’Brien},
  journal={Human Genetics},
  year={2004},
  volume={84},
  pages={185-187}
}
SummaryMonocyte-derived neutrophil chemotactic factor (MDNCF/IL-8, suggested gene symbol IL8) is a cytokine that chemoattracts and activates neutrophils. Using a panel of human-rodent cell hybrids that preferentially segregate human chromosomes and in situ hybridization, the MDNCF/IL-8 gene was placed on the human gene map at position 4q12-q21. This is the same location where at least three other members (platelet factor 4, melanoma growth stimulatory activity, and interferon-γ induced factor… 
Human platelet basic protein/connective tissue activating peptide-III maps in a gene cluster on chromosome 4q12–q13 along with other genes of the β-thromboglobulin superfamily
TLDR
Pro-platelet basic protein is the precursor of the two platelet α-granule proteins, PBP and connective tissue activating peptide-III and at least four other members of this family of small inducible cytokines reside within the same locus, indicating a gene cluster for the β-thromboglobulin family.
Differential modulation of CXCL8 versus CXCL10, by cytokines, PPAR-gamma, or PPAR-alpha agonists, in primary cells from Graves' disease and ophthalmopathy.
TLDR
It is first shown that TFC, OF, and OP secrete CXCL8 and CxCL10 differentially, sustained by specific proinflammatory cytokines or their combination, as well as a different role of the two chemokines in the course of the disease.
IL 1 RAcP ) in human pancreatic interleukin 33 and its receptor complex ( ST 2 L Expression of interleukin 1-like cytokine
Objective Interleukin 33 (IL33) is a cytokine belonging to the IL1 family and it binds to a complex of the ST2L/IL1 receptor accessory protein (IL1RAcP). To define the role of IL33 in fibrogenesis of
Targets of the transcriptional repressor oncoprotein Gfi-1
  • Z. Duan, M. Horwitz
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
Cluster analysis of expression patterns and chromatin immunoprecipitation data reveals that Gfi-1 targets a subset of genes differentiating hematopoietic lineages and therefore plays a relatively superior role in the hierarchy of factors governing stem cell differentiation.
Tumor Necrosis Factor-α and Interleukin-1β Regulate Interleukin-8 Expression in Third Trimester Decidual Cells : Implications for the Genesis of Chorioamnionitis
TLDR
IL-8 is strongly expressed in term decidua during chorioamnionitis, and TNF-alpha and IL-1beta enhance IL-8 expression in termdecidual cells, suggesting that these cytokines are important regulators of chorioamsionitis-related decidual neutrophil infiltration.
Development and characterization of mouse monoclonal antibodies reactive with chicken CXCLi2
TLDR
Inhibition of chCCXCLi2‐induced chemotactic activity on peripheral blood lymphocytes, proliferation of chicken macrophage cells and expression of alpha smooth‐muscle actin in chicken embryonic fibroblast cells by antibodies indicate that these antibodies are capable of blocking chCX CLi2 bioactivity.
Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis
TLDR
The results suggest that some IL-8 and IL-10 SNPs could change individual susceptibility increasing the relative risk in the development of IBS in Blastocystis carriers.
The growth factor independence-1 transcription factor: new functions and new insights.
TLDR
Gfi1 was initially described as an oncoprotein that mediates tumor progression in a mouse model of leukemia; however, recent data suggest that Gfi1 may act as either an oncogene or an anti-proliferative tumor suppressor gene depending on the cell type.
Interleukin-8-251 A / T and CXCR 2 + 1208 C / T Genes Polymorphisms in Chronic Rhinosinusitis
Introduction: IL-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of
Lactobacillus plantarum lipoteichoic acid alleviates TNF-α-induced inflammation in the HT-29 intestinal epithelial cell line
TLDR
The data suggest that pLTA regulates cytokine-mediated immune responses and may be a good candidate for maintaining intestinal homeostasis against excessive inflammation.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 26 REFERENCES
Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8.
To identify possible regulatory sites of the gene expression, we cloned the genomic DNA of human monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8), whose mRNA is induced by IL-1 or TNF and
Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor
TLDR
It was determined that LPS, IL-1, and TNF stimulated the mononuclear cells to produce biologically active MDNCF, which may account for the in vivo capacity ofIL-1 and T NF to induce netrophil infiltrates.
The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes.
TLDR
T lymphocyte chemotactic factor was purified to homogeneity from the conditioned media of phytohemagglutinin-stimulated human blood mononuclear leukocytes and the amino-terminal amino acid sequence of the purified TCF showed identity with neutrophil-activating protein (NAP-1).
Platelet factor 4 is chemotactic for neutrophils and monocytes.
TLDR
The results suggest that the local release of platelet factor 4 may be an important stimulus attracting inflammatory cells to sites of blood vessel injury.
Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).
TLDR
The results suggest that a chemotactic factor for neutrophils, different from IL 1, is produced by LPS-stimulated blood monocytes, and among mononuclear leukocytes, the monocyte was the principal producer of neutrophil chemOTactic factor.
Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells.
TLDR
The results suggest a model in which juxtaposition of genetic loci regulated by antiproliferative signals, such as interferon, next to an oncogene, like ETS1, could effectively short circuit homeostatic control circuits and contribute to the neoplastic state.
Purification and partial biologic characterization of a human lymphocyte-derived peptide with potent neutrophil-stimulating activity.
TLDR
LYNAP shows biochemical and biologic similarities to a recently detected monocyte-derived neutrophil-activating peptide (MONAP), and this finding points toward structure identity or homology of both chemotaxins, MONAP and LYNAP.
γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins
TLDR
The molecular cloning and characterization of a gene regulated by rIFN-γ in U937 cells as well as in human mononuclear cells, fibroblasts and endothelial cells is reported here and may be a member of a family of proteins involved in the inflammatory process.
Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein
TLDR
The reported biological activities of CTAP-III suggest that elevated expression of 9E3 may play a role in producing some of the phenotypic features of RSV-transformed cells.
Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity.
A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion
...
1
2
3
...