Monocyte-derived dendritic cells from Crohn's disease patients exhibit decreased ability to activate T helper type 17 responses in memory cells.

@article{Nieminen2014MonocytederivedDC,
  title={Monocyte-derived dendritic cells from Crohn's disease patients exhibit decreased ability to activate T helper type 17 responses in memory cells.},
  author={Janne K. Nieminen and Taina Sipponen and Martti F{\"a}rkkil{\"a} and Outi Vaarala},
  journal={Clinical and experimental immunology},
  year={2014},
  volume={177 1},
  pages={190-202}
}
An increased activation of interleukin (IL)-17A-producing immune cells is a well-established feature of Crohn's disease (CD). Mechanisms that contribute to this aberrant immune activation are, however, less clear. Given that an enhanced induction of innate-immunity associated cytokines IL-6 and IL-23, which promote IL-17 immunity, is also clearly implicated in CD, we hypothesized that monocyte-derived dendritic cells (moDCs) of CD patient origin would mount exaggerated IL-17A responses in T… CONTINUE READING