Monocyte-derived dendritic cells express and secrete matrix-degrading metalloproteinases and their inhibitors and are imbalanced in multiple sclerosis.

@article{Kouwenhoven2002MonocytederivedDC,
  title={Monocyte-derived dendritic cells express and secrete matrix-degrading metalloproteinases and their inhibitors and are imbalanced in multiple sclerosis.},
  author={Mathilde Kouwenhoven and Volkan {\~O}zenci and Annelie Tjernlund and Mikhail Pashenkov and Mohammed Homman and Rayomand Press and Hans Link},
  journal={Journal of neuroimmunology},
  year={2002},
  volume={126 1-2},
  pages={161-71}
}
Dendritic cells (DC) are antigen-presenting cells (APC) that most efficiently initiate and control immune responses. Migration processes of blood DC are crucial to exert their professional antigen-presenting functions. Matrix-degrading metalloproteinases (MMP) are proteolytic enzymes, which are considered to be key enzymes in extracellular matrix (ECM) turnover and mediators of cell migration. Tissue inhibitors of metalloproteinases (TIMP) are important regulators of MMP activity. Here we… CONTINUE READING
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