Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22.

@article{Hammad2003MonocytederivedDC,
  title={Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22.},
  author={Hamida Hammad and Hermelijn H Smits and C{\'e}line Ratajczak and Asokananthan Nithiananthan and Eddy A. Wierenga and Geoffrey A. Stewart and Alain Jacquet and A. B. Tonnel and J{\"o}el Pestel},
  journal={European cytokine network},
  year={2003},
  volume={14 4},
  pages={
          219-28
        }
}
Dendritic cells (DC) are potent antigen - presenting cells that can orientate the immune response towards a Th1 or a Th2 type. DC produce chemokines that are involved in the recruitment of either Th1 cells, such as IP10 (CXCL10), Th2 cells such as TARC (CCL17) and MDC (CCL22), or non-polarized T cells such as RANTES (CCL5) and MIP-lalpha (CCL3). We investigated whether monocyte-derived DC (MD-DC) generated from healthy donors or from patients sensitive to Dermatophagoides pteronyssinus (Dpt… CONTINUE READING
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