Monocyte chemotaxis: stimulation by specific exosite region in thrombin.

  title={Monocyte chemotaxis: stimulation by specific exosite region in thrombin.},
  author={Rachel Bar-Shavit and Arnold J. Kahn and George D Wilner and John W. Fenton},
  volume={220 4598},
Human alpha-thrombin is a potent chemoattractant for human monocytes, with optimum activity occurring at about 10 nanomoles per liter. A variety of thrombins that were chemically modified to alter procoagulant or esterolytic functions showed a similar optimum activity, but complexes of prothrombin or alpha-thrombin with either antithrombin III or hirudin did not. These findings indicate that the regions in thrombin responsible for monocyte chemotaxis are proximate to those involved in certain… CONTINUE READING
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