Monocyte chemotactic protein-1 and its role in insulin resistance

@article{Sell2007MonocyteCP,
  title={Monocyte chemotactic protein-1 and its role in insulin resistance},
  author={Henrike Sell and J{\"u}rgen Eckel},
  journal={Current Opinion in Lipidology},
  year={2007},
  volume={18},
  pages={258–262}
}
  • H. Sell, J. Eckel
  • Published 1 June 2007
  • Biology, Medicine
  • Current Opinion in Lipidology
Purpose of review In obesity, there is a strong link between increased adipose tissue mass and development of insulin resistance in tissues such as liver and muscle. Under these conditions, adipose tissue synthesizes various pro-inflammatory chemokines such as monocyte chemotactic protein-1. This review provides a summary of recent knowledge on the role of monocyte chemotactic protein-1 in adipose tissue inflammation and insulin resistance. Recent findings Monocyte chemotactic protein-1 is a… 
Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue
TLDR
The observations suggest that MCP-1 does not play a prominent a role in promoting macrophage recruitment into adipose tissue or in systemic insulin resistance.
The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation
TLDR
The results suggest that the C3aR in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance.
MCP-1 deficiency fails to restrain macrophage infiltration into adipose tissue
TLDR
Observations indicate that MCP-1 may not play a prominent a role in promoting macrophage recruitment into adipose tissue or in systemic insulin resistance.
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.
TLDR
It is suggested that macrophages alter the inflammatory state of muscle cells in an obese milieu, inhibiting insulin signaling, and in obesity both adipose tissue and skeletal muscle inflammation may contribute to insulin resistance.
Circulating concentrations of monocyte chemoattractant protein-1 are associated with menopause status in Korean women.
  • K. Park, Kyusik Ahn, S. Lee
  • Medicine, Biology
    Clinica chimica acta; international journal of clinical chemistry
  • 2009
Disruption of Lipid Raft Function Increases Expression and Secretion of Monocyte Chemoattractant Protein-1 in 3T3-L1 Adipocytes
TLDR
The depletion of membrane cholesterol in obese adipocytes may result in dysfunction of lipid rafts, leading to the elevation of proinflammatory signaling and MCP-1 secretion in adipocytes, suggesting perturbation at biosynthesis and secretion.
Circulating monocyte chemoattractant protein-1 links to diabetic retinopathy in type 2 diabetic patients without renal dysfunction
TLDR
It is concluded that circulating MCP-1 level has little correlation with insulin resistance but is linked with diabetic retinopathy in type 2 diabetic patients.
Adipose inflammation, insulin resistance, and cardiovascular disease.
TLDR
Developing therapeutic strategies that target both adipose inflammation and insulin resistance may help to prevent type 2 diabetes and cardiovascular disease in the emerging epidemic of obesity.
Insulin Resistance: A Proinflammatory State Mediated by Lipid-Induced Signaling Dysfunction and Involved in Atherosclerotic Plaque Instability
TLDR
Reduction of FFA levels represents a selective target for modulating insulin resistance, and strong evidence supports the role of free fatty acids (FFAs) in promoting insulin resistance.
Circulating Monocyte Chemoattractant Protein-1 Levels and Lumbar Bone Mineral Density in Korean Women
  • S. Lee
  • Medicine, Biology
    Journal of obesity & metabolic syndrome
  • 2017
TLDR
Circulating MCP-1 levels were not correlated with lumbar BMD regardless of menopausal status, and this study concluded that premenopausal or postmenopausal women without a history of obesity should not be considered to be candidates for menopausal menopause.
...
...

References

SHOWING 1-10 OF 67 REFERENCES
Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle.
TLDR
The data show that adipocytes secrete various adipokines that may be involved in the negative cross-talk between adipose tissue and skeletal muscle assigning a completely novel important role to MCP-1 besides inflammation.
Monocyte chemoattractant protein 1 in obesity and insulin resistance
  • P. Sartipy, D. Loskutoff
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
The results suggest that elevated MCP-1 may induce adipocyte dedifferentiation and contribute to pathologies associated with hyperinsulinemia and obesity, including type II diabetes.
Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects
TLDR
The findings demonstrate that MCP-1 is produced in isolated human adipocytes and support the hypothesis that weight loss is beneficial by improving the low-grade inflammation observed in obesity.
Association between the A–2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and Type 2 diabetes mellitus
TLDR
In a large cohort of Caucasians, the M CP-1 G–2518 gene variant was significantly and negatively correlated with plasma MCP-1 levels and the prevalence of insulin resistance and Type 2 diabetes, adding to recent evidence supporting a role for MCP -1 in pathologies associated with hyperinsulinaemia.
Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.
TLDR
A high-fat diet elevated adipose expression of inflammatory genes, including early induction of MCP-1 and M CP-3, supporting the view that obese adipose tissues contribute to systemic inflammation.
Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance*
TLDR
It is concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-M CP-1 mice.
Regulation of monocyte chemoattractant protein 1 (MCP-1) release by explants of human visceral adipose tissue
TLDR
MCP-1 formation is upregulated over a 48-h incubation of primary explants of visceral adipose tissue from morbidly obese women, and half of this upregulation is dependent upon endogenous TNFα and Il-1β and involves the p38 MAPK and NF-κB pathways.
Relationship between adipocyte size and adipokine expression and secretion.
TLDR
There seems to be a differential expression of pro- and antiinflammatory factors with increasing adipocyte size resulting in a shift toward dominance of proinflammatory adipokines largely as a result of a dysregulation of hypertrophic, very large cells.
...
...