Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis.

  title={Monocyte chemoattractant proteins in the pathogenesis of systemic sclerosis.},
  author={J{\"o}rg H. W. Distler and Alfiya Akhmetshina and Georg Schett and Oliver Distler},
  volume={48 2},
Activation of the immune system and increased synthesis of extracellular matrix proteins by fibroblasts are hallmarks in the pathogenesis of SSc. The molecular mechanisms underlying the infiltration of inflammatory cells into the skin and the subsequent activation of fibroblasts are still largely unknown. Chemokines are a family of small molecules that are classified according to the position of the NH(2)-terminal cysteine motif. Recent data indicate that chemokines and in particular two… CONTINUE READING
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