Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice.

@article{Chow2006MonocyteCP,
  title={Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice.},
  author={Fiona Y F Chow and David J Nikolic-Paterson and Elyce Ozols and Robert C. Atkins and Bernard Rollin and Gregory H. Tesch},
  journal={Kidney international},
  year={2006},
  volume={69 1},
  pages={73-80}
}
Diabetic nephropathy involves a renal inflammatory response induced by the diabetic milieu. Macrophages accumulate in diabetic kidneys in association with the local upregulation of monocyte chemoattractant protein-1 (MCP-1); however, the contribution of macrophages to renal injury and the importance of MCP-1 to their accrual are unclear. Therefore, we examined the progression of streptozotocin (STZ)-induced diabetic nephropathy in mice deficient in MCP-1 in order to explore the role of MCP-1… CONTINUE READING
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