Monocyte chemoattractant protein 1-mediated migration of mesenchymal stem cells is a source of intimal hyperplasia.

@article{Grudzinska2013MonocyteCP,
  title={Monocyte chemoattractant protein 1-mediated migration of mesenchymal stem cells is a source of intimal hyperplasia.},
  author={Monika K. Grudzinska and Ewa Kurzejamska and Krzysztof Bojakowski and Joanna Soin and Michael H. Lehmann and Hans Reinecke and Charles E Murry and Cecilia Soderberg-Naucler and Piotr Religa},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 6},
  pages={1271-9}
}
OBJECTIVE Intimal hyperplasia is considered to be a healing response and is a major cause of vessel narrowing after injury, where migration of vascular progenitor cells contributes to pathological events, including transplant arteriosclerosis. APPROACH AND RESULTS In this study, we used a rat aortic-allograft model to identify the predominant cell types associated with transplant arteriosclerosis and to identify factors important in their recruitment into the graft. Transplantation of labeled… CONTINUE READING

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