Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy.

@article{Fischer2008MonocyteCP,
  title={Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy.},
  author={Stefan Fischer and C. Kleinschnitz and Marcus Mueller and Igor Kobsar and Chi Wang Ip and Barrett J. Rollins and Rudolf Martini},
  journal={Molecular and cellular neurosciences},
  year={2008},
  volume={37 2},
  pages={359-66}
}
Macrophages are critically involved in the pathogenesis of genetically caused demyelination, as it occurs in models for inherited demyelinating neuropathies. It is presently unknown which factors link the Schwann cell-based myelin mutation to the activation of endoneurial macrophages. Here we identified the chemokine monocyte chemoattractant protein-1 (MCP-1) as a first and crucial factor upregulated in Schwann cells of mice heterozygously deficient for the myelin protein zero. The chemokine… CONTINUE READING

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