Monocyte chemoattractant protein-1-deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet

@inproceedings{Kassel2010MonocyteCP,
  title={Monocyte chemoattractant protein-1-deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet},
  author={Karen M. Kassel and Grace L. Guo and Ossama W. Tawfik and James P. Luyendyk},
  booktitle={Laboratory Investigation},
  year={2010}
}
Monocyte chemoattractant protein-1 (MCP-1, Ccl2) expression is increased in livers of patients with nonalcoholic steatohepatitis and in murine models of steatohepatitis. Several studies in rodents indicate that MCP-1 contributes to liver steatosis induced by feeding a high-fat diet. However, the extent of MCP-1 involvement in the widely utilized methionine–choline-deficient (MCD) diet model of steatohepatitis has not been determined. We tested the hypothesis that MCP-1 contributes to… CONTINUE READING
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