Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset.

@article{Takada2010MonocyteCP,
  title={Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset.},
  author={Yasuhiro Takada and Tadakazu Hisamatsu and Nobuhiko Kamada and Mina Tokutake Kitazume and Haruki Honda and Yosuke Oshima and Riko Saito and Tetsuro Takayama and Taku Kobayashi and Hiroshi Chinen and Yohei Mikami and T. Hosokawa Kanai and Susumu Okamoto and Toshifumi Hibi},
  journal={Journal of immunology},
  year={2010},
  volume={184 5},
  pages={2671-6}
}
Lamina propria macrophages (LPMs) spontaneously produce large amounts of anti-inflammatory IL-10 and play a central role in regulation of immune responses against commensal bacteria. MCP-1 is a chemokine that plays an important role in recruitment of monocytes and macrophages to inflamed tissues. We demonstrated that, in addition to IL-10, LPMs produced large amounts of MCP-1, even in a steady state. MCP-1 deficiency caused impaired IL-10 production by LPMs and led to exacerbation of dextran… CONTINUE READING
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