Monocyte chemoattractant protein-1 (MCP-1): an overview.

  title={Monocyte chemoattractant protein-1 (MCP-1): an overview.},
  author={Satish L. Deshmane and Sergey G. Kremlev and Shohreh Amini and Bassel E. Sawaya},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  volume={29 6},
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four families on the basis of the number and spacing of the conserved cysteine residues in the N-terminus of the protein. Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and… CONTINUE READING
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